Although cancer stem cells are likely to be the cells that initially undergo transformation by mutations or viral infection, almost nothing is known about the host immune system’s ability to recognize and respond to them.

My laboratory is interested in deepening our understanding of these issues. We are particularly interested in the study of a special subset of lymphocytes, called natural killer (NK) cells, which have been described to be critically important in the innate immune response to cells undergoing malignant transformation.